• When a comparison operator is used on uint256 values, it requires the EVM to perform a subtraction operation between the two values, which takes up more gas than a simple check for equality.
• When we use !=X for comparison, the EVM checks if the value is non-zero by simply checking the zero flag, which is more efficient in terms of gas cost compared to checking for a positive value using > X. This is because checking for a positive value requires the EVM to perform a subtraction operation to determine whether the value is positive or not.

Therefore, in Solidity, it is more gas-efficient to use !=X instead of > X when comparing unsigned integer values.